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BMX-IN-1

Catalog #: 5123
1 Citation Datasheet / COA / SDS
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BMX-IN-1 | CAS No. 1431525-23-3 | Additional RTK Inhibitors
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Description: Potent and irreversible BMX inhibitor

Chemical Name: N-[2-Methyl-5-[9-[4-[(methylsulfonyl)amino]phenyl]-2-oxobenzo[h]-1,6-naphthyridin-1(2H)-yl]phenyl]-2-propenamide

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

BMX-IN-1 is a potent and irreversible BMX inhibitor (IC50 = 25 nM). Covalently modifies Cysteine 496. Demonstrates selectivity over other Tec family members with identically positioned reactive cysteine residue in vitro. Reduces cell number and induces apoptosis in prostate cancer cell lines. Also inhibits proliferation and reduces viability in HeLa and SiHa cell lines.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BMX-IN-1 is reviewed on the chemical probes website.

Technical Data

M.Wt:
524.59
Formula:
C29H24N4O4S
Solubility:
Soluble to 1 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1431525-23-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Dana-Farber Cancer Institute.

Product Datasheets

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Citation for BMX-IN-1

The citations listed below are publications that use Tocris products. Selected citations for BMX-IN-1 include:

1 Citation: Showing 1 - 1

  1. Probing the signaling requirements for naive human pluripotency by high-throughput chemical screening.
    Authors: Rudolf Et al.
    Cell Rep  2021;35:109233

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