BMS CCR2 22

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Effect of CCR2 inhibitor-loaded lipid micelles on inflammatory cell migration and cardiac function after myocardial infarction
   J Wang, MJ Seo, MB Deci, BR Weil, JM Canty, J Nguyen
   Int J Nanomedicine, 2018;13(0):6441-6451.
2. CCR2(-) and CCR2(+) corneal macrophages exhibit distinct characteristics and balance inflammatory responses after epithelial abrasion
   J Liu, Y Xue, D Dong, C Xiao, C Lin, H Wang, F Song, T Fu, Z Wang, J Chen, H Pan, Y Li, D Cai, Z Li
   Mucosal Immunol, 2017;0(0):.
3. CCR2 acts as scavenger for CCL2 during monocyte chemotaxis.
   Volpe S, Cameroni E, Moepps B
   PLoS ONE, 2012;7(5):e37208.
4. Minocycline, a microglial inhibitor, blocks spinal CCL2-induced heat hyperalgesia and augmentation of glutamatergic transmission in substantia gelatinosa neurons.
   Huang C, Chen Y, Li A, Lu J, Wang H
   J Neuroinflammation, 2014;11(0):7.
5. Discovery of disubstituted cyclohexanes as a new class of CC chemokine receptor 2 antagonists.
   Cherney et al.
   J.Med.Chem., 2008;51:721
6. CCR2 receptor ligands inhibit Ca_v3.2 T-type calcium channels.
   You et al.
   Mol.Pharmacol., 2010;77:211

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