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BMS 753

Catalog #: 3505
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3505/10
3505/50
BMS 753 | CAS No. 215307-86-1 | Retinoic Acid Receptor Agonists
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Description: RARα-selective agonist

Chemical Name: 4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]benzoic acid

Purity: ≥99%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

BMS 753 is a RARα-selective agonist (Ki = 2 nM).

Technical Data

M.Wt:
351.4
Formula:
C21H21NO4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
215307-86-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Retinoic acid induces Sertoli cell paracrine signals for spermatogonia differentiation but cell autonomously drives spermatocyte meiosis.
    Raverdeau M, Gely-Pernot A, Feret B, Dennefeld C, Benoit G, Davidson I, Chambon P, Mark M, Ghyselinck N
    Proc Natl Acad Sci U S A, 2012;109(41):16582-7.
  2. Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists.
    Gehin et al.
    Chem.Biol., 1999;6:519

Product Datasheets

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Reconstitution Calculator

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Citations for BMS 753

The citations listed below are publications that use Tocris products. Selected citations for BMS 753 include:

3 Citations: Showing 1 - 3

  1. Molecular and electrophysiological evaluation of human cardiomyocyte subtypes to facilitate generation of composite cardiac models.
    Authors: Vincent M Et al.
    J Tissue Eng  2022;13:20417314221127908
  2. Retinoic Acid Receptor Alpha Represses a Th9 Transcriptional and Epigenomic Program to Reduce Allergic Pathology.
    Authors: Yuan Et al.
    Immunity  2019;50:106-120.e10
  3. Retinoic acid induces Sertoli cell paracrine signals for spermatogonia differentiation but cell autonomously drives spermatocyte meiosis.
    Authors: Raverdeau Et al.
    Proc Natl Acad Sci U S A  2012;109:16582

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