BMS 566419

Catalog #: 5492 Datasheet / COA / SDS

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BMS 566419 | CAS No. 566161-24-8 | Dehydrogenase Inhibitors

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Description: Inosine monophosphatase dehydrogenase (IMPDH) inhibitor

Chemical Name: N-[1-[6-(4-Ethyl-1-piperazinyl)-3-pyridinyl]-1-methylethyl]-2-fluoro-9,10-dihydro-9-oxo-3-acridinecarboxamide

Purity: ≥98%

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Biological Activity

BMS 566419 is a potent inosine monophosphate dehydrogenase (IMPDH) inhibitor (IC₅₀ = 17 nM). Inhibits proliferation of human T-lymphoblasts and PBMCs in vitro. Reduces paw swelling in a rat adjuvant arthritis model. Orally available.

Technical Data

M.Wt:

487.57

Formula:

C₂₈H₃₀FN₅O₂

Solubility:

Soluble to 50 mM in 1eq. HCl and to 100 mM in DMSO

Purity:

≥98%

Storage:

Store at +4°C

CAS No:

566161-24-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419).
Watterson et al.
J.Med.Chem., 2007;50:3730

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