BIX NHE1 inhibitor

Catalog #: 5512
1 Citation Datasheet / COA / SDS

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5512/10
5512/50

BIX NHE1 inhibitor | CAS No. 1422252-46-7 | Na+/Ca2+ Exchanger Inhibitors

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Description: Potent and selective NHE1 inhibitor

Chemical Name: 4-(1-Acetyl-4-piperidinyl)-N-(aminoiminomethyl)-3-(trifluoromethyl)benzamide hydrochloride

Purity: ≥98%

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Product Details

Citations (1)

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Biological Activity

BIX NHE1 inhibitor is a potent and selective NHE1 inhibitor (IC₅₀ = 31 nM). Selective for NHE1 over NHE2 and NHE3. Prevents ischemic damage in an ischemia reperfusion injury isolated rat heart model ex vivo. Prevents phenylephrine-induced cardiomyocyte hypertrophy in vitro, and attenuates cardiac hypertrophy and left ventricular dysfunction postinfarction in rats. Orally bioavailable.

Technical Data

M.Wt:

392.8

Formula:

C₁₆H₁₉F₃N₄O₂.HCl

Solubility:

Soluble to 50 mM in DMSO

Purity:

≥98%

Storage:

Desiccate at RT

CAS No:

1422252-46-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Identification of a potent sodium hydrogen exchanger isoform 1 (NHE1) inhibitor with a suitable profile for chronic dosing and demonstrated cardioprotective effects in a preclinical model of myocardial infarction in the rat.
Huber et al.
J.Med.Chem., 2012;55:7114
Early and transient sodium-hydrogen exchanger isoform 1 inhibition attenuates subsequent cardiac hypertrophy and heart failure following coronary artery ligation.
Kilić et al.
J.Pharmacol.Exp.Ther., 2014;351:492

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Citation for BIX NHE1 inhibitor

The citations listed below are publications that use Tocris products. Selected citations for BIX NHE1 inhibitor include:

1 Citation: Showing 1 - 1

Adhesion-mediated mechanosignaling forces mitohormesis.
Authors: Valerie M Et al.
Cell Metab 2021;33:1322-1341.e13

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