BIBR 1532
Chemical Name: 2-[[(2E)-3-(2-Naphthalenyl)-1-oxo-2-butenyl1-yl]amino]benzoic acid
Purity: ≥98%
Biological Activity
BIBR 1532 is a selective telomerase inhibitor (IC50 values are 93, > 100000 and > 100000 nM for human telomerase, human RNA polymerase I and human RNA polymerase II + III respectively). Causes telomere shortening in exponentially growing NCI-H460 lung carcinoma cells and eventual growth arrest.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Gastrointestinal cancer cells treatment with bevacizumab activates a VEGF autoregulatory mechanism involving telomerase catalytic subunit hTERT via PI3K-AKT, HIF-1? and VEGF receptors
N Mahfouz, R Tahtouh, N Alaaeddine, J El Hajj, R Sarkis, R Hachem, I Raad, G Hilal
PLoS ONE, 2017;12(6):e0179202. -
A highly selective telomerase inhibitor limiting human cell proliferation.
Damm et al.
EMBO J., 2001;20:6958 -
Telomerase and its potential for therapeutic intervention.
Phatak and Burger
Br.J.Pharmacol., 2007;152:1003 -
Telomerase inhibitors and 'T-oligo' as caner therapeutics: contrasting molecular mechanisms of cytotoxicity.
Rankin et al.
Anticancer Drugs, 2008;19:329
Product Datasheets
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Citations for BIBR 1532
The citations listed below are publications that use Tocris products. Selected citations for BIBR 1532 include:
2 Citations: Showing 1 - 2
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Critical Role for Telomerase in the Mechanism of Flow-Mediated Dilation in the Human Microcirculation.
Authors: Beyer Et al.
Circ Res 2016;118:856
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Telomerase efficiently elongates highly transcribing telomeres in human cancer cells.
Authors: Farnung Et al.
PLoS One 2012;7:e35714
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