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BI 3231

Catalog #: 8039 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
8039/5
BI 3231 | CAS No. 2894848-07-6 | Dehydrogenase Inhibitors
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Description: Potent and selective hydroxysteroid 17β dehydrogenase 13 (HSD17B13) inhibitor

Chemical Name: 1-[[5-(2,4-Difluoro-3-hydroxyphenyl)-1,3,4-thiadiazol-2-yl]methyl]-3-ethyl-5-methyl-2,4(1H,3H)pyrimidinedione

Purity: ≥98%

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Biological Activity

BI 3231 is a potent and selective hydroxysteroid 17β dehydrogenase 13 (HSD17B13) inhibitor (IC50 values are 1 nM and 13 nM at hHSD17B13 and mHSD17B13 respectively; Ki = 0.7 nM). Reduces palmitic acid-induced toxicity in hepatocytes. Suitable for use in vivo and in vitro.

Technical Data

M.Wt:
380.37
Formula:
C16H14F2N4O3S
Solubility:
Soluble to 10 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2894848-07-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BI 3231 probe summary on the SGC website.

Product Datasheets

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