Home / Prostanoid Receptor Antagonists / BGC 20-1531 hydrochloride

BGC 20-1531 hydrochloride

Catalog #: 5327
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5327/10
BGC 20-1531 hydrochloride | CAS No. 1962928-26-2 | Prostanoid Receptor Antagonists
1 Image
Description: High affinity and selective EP4 antagonist
Alternative Names: PGN 1531

Chemical Name: 4-[[4-(5-Methoxy-2-pyridinyl)phenoxy]methyl]-5-methyl-N-[(2-methylphenyl)sulfonyl]-2-furancarboxamide hydrochloride

Purity: ≥98%

Product Details
Citations (2)
Supplemental Products
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

BGC 20-1531 hydrochloride is a high affinity and selective EP4 antagonist (Ki = 3 nM). Exhibits >2500-fold selectivity for EP4 over EP2 and EP3. Also selective over a range of other prostanoid receptors, ion channels, transporters and enzymes. Inhibits PGE2-induced vasodilation of middle cerebral and meningeal arteries in vitro, and carotid blood flow in vivo. Orally bioavailable.

Technical Data

M.Wt:
529
Formula:
C26H24N2O6S.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
1962928-26-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. From virtual to clinical: The discovery of PGN-1531, a novel antagonist of the prostanoid EP4 receptor.
    Sutton et al.
    Bioorg.Med.Chem.Lett., 2014;24:2212

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for BGC 20-1531 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for BGC 20-1531 hydrochloride include:

2 Citations: Showing 1 - 2

  1. Tumor-Derived Lysophosphatidic Acid Blunts Protective Type I Interferon Responses in Ovarian Cancer.
    Authors: David Et al.
    Cancer Discov  2022;12:1904-1921
  2. Autocrine-paracrine prostaglandin E2 signaling restricts TLR4 internalization and TRIF signaling.
    Authors: Perkins Et al.
    Nat.Immunol.  2018;19:1309

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs
Loading...

Reviews for BGC 20-1531 hydrochloride

There are currently no reviews for this product. Be the first to review BGC 20-1531 hydrochloride and earn rewards!

Have you used BGC 20-1531 hydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.