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BAY 593

Catalog #: 8113 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
8113/5
BAY 593 | CAS No. 2413020-57-0 | Other Transferase Inhibitors
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Description: Geranylgeranyltransferase-I (GGTase-1) inhibitor

Chemical Name: (2R)-3,3,3-Trifluoro-2-methoxy-1-[(7R)-7-(2-methoxyphenyl)-3,9-diazaspiro[5.5]undec-3-yl]-2-phenyl-1-propanone hydrochloride

Purity: ≥98%

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Biological Activity

BAY 593 is a geranylgeranyltransferase-I (GGTase-1) inhibitor. Blocks activation of Rho-GTPases to inactivate YAP1/TAZ signaling. Dose-dependently inhibits growth of tumors in xenograft mouse models (IC50 values are 38.4 nM and 564 nM in MT-1080 and MDA-MB-231 cells respectively) and PXF 541 xenografts. Orally bioavailable and suitable for use in vivo.

Technical Data

M.Wt:
513
Formula:
C26H31F3N2O3.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2413020-57-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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