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BAY 390

Catalog #: 7978 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7978/10
BAY 390 | CAS No. 2741956-55-6 | TRPA1 Blockers
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Description: Potent and selective TRPA1 antagonist. Brain penetrant and orally bioavailable

Chemical Name: (1R,2R)-2-[(4-Fluorophenyl)amino]-1-(trifluoromethyl)cyclohexanol

Purity: ≥98%

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Biological Activity

BAY 390 is a potent and selective transient receptor potential ankyrin 1 (TRPA1) antagonist (IC50 values are 16, 63 and 82 nM for hTRPA1 FLIPR, rTRPA1 FLIPR and hTRPA1 Ephys, respectively). In vivo, BAY 390 exhibits efficacy in rat models of inflammatory and neuropathic pain. BAY 390 is orally bioavailable and brain penetrant. Suitable to use as an in vitro or in vivo probe to investigate the roles of TRPA1 in models of acute, inflammatory, and neuropathic pain.

Technical Data

M.Wt:
277.26
Formula:
C13H15F4NO
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2741956-55-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY 390 probe summary on the SGC website.

Product Datasheets

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