BAY 299

Biological Activity

BAY 299 is a potent and selective BRD1 and TAF1 inhibitor (IC₅₀ values are 6-67 and 8-13 nM, respectively). Displays selectivity over other bromodomains (>30-fold over other members of the BRPF family; BRD9 and ATAD2; >300-fold over BRD4). Displays BRD1 and TAF1 inhibition in a NanoBRET cell assay. Inhibits binding of BRD1 and TAF1 to histone H4 (IC₅₀ values are 575 nM and 0.9 μM, respectively) and histone H3.3 (IC₅₀ values are 825 nM and 1.4 μM, respectively).

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BAY 299 is reviewed on the Chemical Probes website.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Background References

1. Benzoisoquinolinediones as potent and selective inhibitors of BRPF2 and TAF1/TAF1L bromodomains.
   Bouche et al.
   J.Med.Chem., 2017;60:4002
2. Crosstalk between epigenetic readers regulates the MOZ/MORF HAT complexes.
   Klein et al.
   Epigenetics, 2014;9:186

Product Datasheets