Bax channel blocker
Chemical Name: 3,6-Dibromo-α-(1-piperazinylmethyl)-9H-carbazole-9-ethanol dihydrochloride
Purity: ≥98%
Biological Activity
Bax channel blocker is a allosteric inhibitor of Bax channel activation. Binds inactive Bax at allosteric site and inhibits tBID-mediated Bax activation (IC50 = 3.3 μM). Selectively inhibits Bax-dependent apoptosis. Potent inhibitor of Bax-mediated mitochondrial cytochrome c release (IC50 = 0.52 μM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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3,6-Dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via Bax channel modulation.
Bombrun et al.
J.Med.Chem., 2003;46:21 -
Small-molecule allosteric inhibitors of BAX.
Garner et al.
Nat.Chem.Biol., 2019;15:322
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Citations for Bax channel blocker
The citations listed below are publications that use Tocris products. Selected citations for Bax channel blocker include:
2 Citations: Showing 1 - 2
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Feedback activation of AMPK-mediated autophagy acceleration is a key resistance mechanism against SCD1 inhibitor-induced cell growth inhibition.
Authors: Ono Et al.
PLoS One 2017;12:e0181243
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Vacuolin-1 inhibits autophagy by impairing lysosomal maturation via PIKfyve inhibition.
Authors: Sano Et al.
FEBS Lett 2016;590:1576
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