BAM (8-22)
Purity: ≥95%
Biological Activity
BAM (8-22) is an endogenous peptide fragment that is a potent agonist for MRGPRX1 (EC50 values are 8 - 150 nM). It was first isolated from bovine adrenal medulla. Unlike BAM 22P (Cat. No. 1650), BAM (8-22) does not contain the met-enkephalin motif therefore displays no affinity for opioid receptors. BAM (8-22) augments scratching behavior in a cholestatic pruritus mice model. BAM (8-22) attenuates bone cancer pain in mice.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Modulation of ion channels and synaptic transmission by a human sensory neuron-specific G-protein-coupled receptor, SNSR4/mrgX1, heterologously expressed in cultured rat neurons.
Chen and Ikeda
J.Neurosci., 2004;24:5044 -
Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs.
Lembo et al.
Nat.Neurosci., 2002;5:201 -
Two faces for an opioid peptide - and more receptors for pain research.
Simonin and Kieffer
Nat.Neurosci., 2002;5:185 -
Pharmacology and signaling of MAS-related G protein-coupled receptors.
Solinski et al.
Pharmacol.Rev., 2014;66:570
Product Datasheets
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Citations for BAM (8-22)
The citations listed below are publications that use Tocris products. Selected citations for BAM (8-22) include:
5 Citations: Showing 1 - 5
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Activation of MrgprA3 and MrgprC11 on bladder-innervating afferents induces peripheral and central hypersensitivity to bladder distension.
Authors: Grundy Et al.
J.Neurosci. 2021;41:3900
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BAM8-22 and its receptor MRGPRX1 may attribute to cholestatic pruritus.
Authors: Sanjel Et al.
Sci.Rep. 2019;9:10888
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Effects of intravesical administration of sensory neuron-specific receptor agonist on voiding function in rats with CP-induced cystitis.
Authors: Honda Et al.
Cent European J Urol 2019;72:142
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Peptidomimetics of Arg-Phe-NH2 as small molecule agonists of Mas-related gene C (MrgC) receptors.
Authors: Hin Et al.
Bioorg Med Chem 2014;22:5831
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Itch and analgesia resulting from intrathecal application of morphine: contrasting effects on different populations of trigeminothalamic tract neurons.
Authors: Moser and Giesler
J Neurosci 2013;33:6093
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