Home / Diacylglycerol O-Acyltransferase (DGAT) Inhibitors / AZD 3988

AZD 3988

Catalog #: 4837
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4837/10
4837/50
AZD 3988 | CAS No. 892489-52-0 | Diacylglycerol O-Acyltransferase (DGAT) Inhibitors
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Description: Potent and selective DGAT-1 inhibitor

Chemical Name: trans-4-[-[[[5-[(3,4-Difluorophenyl)amino]-1,3,4-oxadiazol-2-yl]carbonyl]amino]phenyl]cyclohexaneacetic acid

Purity: ≥98%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

AZD 3988 is a potent and selective diacylglycerol acyltransferase (DGAT-1) inhibitor (IC50 = 0.6 nM). Exhibits selectivity for DGAT-1 over DGAT-2, Kv11.1 (hERG) and cytochrome P450 enzymes. Suppresses triacylglyceride (TAG) plasma excursion and adipose tissue TAG synthesis in rats. Reduces body weight of diet-induced obese rats. Cell permeable and orally bioavailable.

Technical Data

M.Wt:
456.44
Formula:
C23H22F2N4O4
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in 1eq. NaOH with gentle warming
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
892489-52-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of AstraZeneca UK Ltd.

Product Datasheets

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Citations for AZD 3988

The citations listed below are publications that use Tocris products. Selected citations for AZD 3988 include:

3 Citations: Showing 1 - 3

  1. Oxidative stress from DGAT1 oncoprotein inhibition in melanoma suppresses tumor growth when ROS defenses are also breached.
    Authors: Andris Et al.
    Cell Rep  2022;39:110995
  2. A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition.
    Authors: Mahoney Et al.
    Nat Commun  2019;10:96
  3. A Novel Role for Triglyceride Metabolism in Foxp3 Expression.
    Authors: Benedikt M Et al.
    Front Immunol  2019;10:1860

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