Home / PFKFB3 Inhibitors / AZ PFKFB3 67

AZ PFKFB3 67

Catalog #: 5742
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5742/10
5742/50
AZ PFKFB3 67 | CAS No. 1704741-11-6 | PFKFB3 Inhibitors
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Description: Potent and selective PFKFB3 inhibitor

Chemical Name: (2S)-N-[4-[[3-Cyano-1-[(3,5-dimethyl-4-isoxazolyl)methyl]-1H-indol-5-yl]oxy]phenyl]-2-pyrrolidinecarboxamide

Purity: ≥98%

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

AZ PFKFB3 67 is a potent and selective PFKFB3 inhibitor (IC50 values are 11, 159 and 1130 nM for PFKFB3, PFKFB2 and PFKFB1 respectively).

Technical Data

M.Wt:
455.51
Formula:
C26H25N5O3
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1704741-11-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for AZ PFKFB3 67

The citations listed below are publications that use Tocris products. Selected citations for AZ PFKFB3 67 include:

4 Citations: Showing 1 - 4

  1. Oxidative pentose phosphate pathway controls vascular mural cell coverage by regulating extracellular matrix composition.
    Authors: Mihaela Et al.
    Nat Metab  2022;4:123-140
  2. Suppression of myeloid PFKFB3-driven glycolysis protects mice from choroidal neovascularization.
    Authors: Zheng Et al.
    Br J Pharmacol  2022;179:5109-5131
  3. PFKFB3-dependent glucose metabolism regulates 3T3-L1 adipocyte development.
    Authors: Satoshi Et al.
    FASEB J  2021;35:e21728
  4. LncRNA wires up Hippo and Hedgehog signaling to reprogramme glucose metabolism.
    Authors: Zheng Et al.
    EMBO J  2017;36:3325

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