AZ PFKFB3 26

Catalog # Availability Size / Price Qty
5675/10
5675/50
AZ PFKFB3 26 | CAS No. 1704740-52-2 | PFKFB3 Inhibitors
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Description: Potent and selective PFKFB3 inhibitor

Chemical Name: (2S)-N-[4-[[3-Cyano-1-(2-methylpropyl)-1H-indol-5-yl]oxy]phenyl]-2-pyrrolidinecarboxamide

Purity: ≥98%

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Biological Activity

AZ PFKFB3 26 is a potent and selective PFKFB3 inhibitor (IC50 = 0.023 μM). Selective for PFKFB3 over PFKFB2 and PFKFB1 isoforms (IC50 values are 0.382 μM and 2.06 μM, respectively). Reduces levels of fructose-1,6-bisphosphate in A549 cells (IC50 = 0.343 μM). Exhibits no significant inhibition of other kinases.

Technical Data

M.Wt:
402.49
Formula:
C24H26N4O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1704740-52-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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