AZ 1729
Chemical Name: 4-Fluoro-N-[3-[2-[(aminoiminomethyl)amino]-4-methyl-5-thiazolyl]phenyl]benzamide
Purity: ≥98%
Biological Activity
AZ 1729 is a FFA2 allosteric agonist. Inhibits forskolin-induced cAMP increase and stimulates 35SGTPγS binding in biochemical assays (pEC50 values are 6.9 and 7.23, respectively). Binds at allosteric binding site. In functional assays, displays positive allosteric modulation of FFA-induced Gi signaling and negative allosteric modulation of FFA-induced Gq/G11 signaling. Inhibits lipolytic effect of isoproterenol (pEC50 = 5.03) and induces migration of human neutrophils in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A novel allosteric activator of free fatty acid 2 receptor displays unique Gi-functional bias.
Bolognini et al.
J.Biol.Chem., 2016;291:18915 -
A single extracellular amino acid in free fatty acid receptor 2 defines antagonist species selectivity and G protein selection bias.
Sergeev et al.
Sci.Rep., 2017;7:13741
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