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AUTAC4

Catalog #: 7699 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7699/5
AUTAC4 | CAS No. 2267315-04-6 | Active Degraders
1 Image
Description: Mitochondrial targeting AUTAC Degrader

Chemical Name: N-[(16R)-16-[[[2-Amino-9-[(4-fluorophenyl)methyl]-6,9-dihydro-6-oxo-1H-purin-8-yl]thio]methyl]-15,18-dioxo-4,7,10-trioxa-14,17-diazanonadec-1-yl]-α-oxo-2-phenyl-1H-indole-3-acetamide

Purity: ≥98%

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Biological Activity

AUTAC4 is an autophagy-targeting chimera targeting mitochondria. Comprises p-fluorobenzyl guanine joined by a PEG linker to a 2-phenylindole-3-glyoxyaminde ligand for the translocator protein on the outer mitochondrial membrane. It delivers a guanine tag to the mitochondrial membrane and promotes mitophagy of damaged mitochondria. In Down syndrome cells, AUTAC4 degrades impaired mitochondria and promotes the generation of functionally normal mitochondria.

Technical Data

M.Wt:
869.97
Formula:
C43H48FN9O8S
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2267315-04-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Tohoku Techno Arch.

Product Datasheets

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Reconstitution Calculator

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