AUNP 12

Biological Activity

AUNP 12 is an immune checkpoint modulator targeting the programmed cell death 1 (PD-1) signaling pathway. It inhibits the interaction between PD-1 and its ligands, PD-L1 and PD-L2. In the mouse splenocyte assay system, AUNP 12 rescues proliferation (EC₅₀ values are 17 and 16 nM for PD-L1 and PD-L2, respectively) and enhances T-cell activity by restoring IFNγ release inhibited by PD-L1 and PD-L2 (EC₅₀ values are 49 nM and 51 nM respectively). In a mouse Renca renal cell carcinoma model, AUNP 12 shows an additive antitumor effect when combined with Cyclophosphamide (Cat. No. 4091).

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets