ATI 2341

Catalog #: 5795 Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
5795/1

1 Image

Description: CXCR4 allosteric agonist

Purity: ≥95%

View All Products for Chemokine Receptor Agonists

Product Details

Supplemental Products

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

ATI 2341 is a CXCR4 allosteric agonist (EC₅₀ = 194 nM). Induces chemotaxis in CXCR4-expressing cells in vitro. Mobilizes polymorphonuclear neutrophils (PMNs) and hematopoietic stem and progenitor cells (HSPCs) from bone marrow niche in vivo. Exhibits biased signaling towards G_i proteins over G₁₃ and β-arrestin.

Technical Data

M.Wt:

2256.82

Formula:

C₁₀₄H₁₇₈N₂₆O₂₅S₂

Sequence:

MGYQKKLRSMTDKYRL

(Modification: Met-1 = N-terminal Palmitoyl)

Solubility:

Soluble to 1 mg/ml in water

Purity:

≥95%

Storage:

Store at -20°C

CAS No:

1337878-62-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells.
Tchernychev et al.
Proc.Natl.Acad.Sci.U.S.A., 2010;107:22255
Studying the binding interactions of allosteric agonists and antagonists of the CXCR4 receptor.
Planesas et al.
J.Mol.Graph Model., 2015;60:1
Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein.
Quoyer et al.
Proc.Natl.Acad.Sci.U.S.A., 2013;110:E5088

Product Datasheets

COA view current batch

Or select another batch:

View Batch

SDS

Reconstitution Calculator

Molarity Calculator

Reconstitution Calculator

Molarity Calculator

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Peptide FAQs

Reviews for ATI 2341

There are currently no reviews for this product. Be the first to review ATI 2341 and earn rewards!

Have you used ATI 2341?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.