Astressin
Purity: ≥95%
Biological Activity
Astressin is a potent corticotropin-releasing factor (CRF) receptor antagonist (Ki values are 2, 1.5 and 1 nM at CRF1, CRF2α and CRF2β). Reduces ACTH secretion, blocks delayed gastric emptying and is neuroprotective in vivo.Technical Data
(Modifications: Phe-1 = D-Phe, X-10 = X-27 = Nle, Glu-19 = γ-Glu, Lys-22 = ε-Lys, Cyclized: Glu-19 - Lys-22, Ile-30 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Potent, structurally constrained agonists and competitive antagonists of corticotropin-releasing factor.
Gulyas et al.
Proc.Natl.Acad.Sci.U.S.A., 1995;92:10575 -
Astressin, a novel and potent CRF antagonist, is neuroprotective in the hippocampus when administered after a seizure.
Maecker et al.
Brain Res., 1997;744:166 -
Peripheral injection of a new corticotropin-releasing factor (CRF) antagonist, astressin, blocks peripheral CRF- and abdominal surgery-induced delayed gastric emptying in rats.
Martinez et al.
J.Pharmacol.Exp.Ther., 1999;290:629 -
Corticotropin releasing factor receptors and their ligand family.
Perrin and Vale
Ann.N.Y.Acad.Sci., 1999;885:312
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