ARP 101

Catalog #: 2622
3 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
2622/5

ARP 101 | CAS No. 849773-63-3 | Synthetic Metalloprotease Inhibitors

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Description: Inhibitor of MMP-2

Chemical Name: (R)-N-Hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamide

Purity: ≥99%

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Product Details

Citations (3)

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

ARP 101 is a selective inhibitor of MMP-2 that displays ~ 600-fold selectivity over MMP-1 (IC₅₀ values are 0.81 and 486 nM respectively).

Technical Data

M.Wt:

406.5

Formula:

C₂₀H₂₆N₂O₅S

Solubility:

Soluble to 100 mM in DMSO and to 25 mM in ethanol

Purity:

≥99%

Storage:

Desiccate at +4°C

CAS No:

849773-63-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Up-Regulated Expression of Matrix Metalloproteinases in Endothelial Cells Mediates Platelet Microvesicle-Induced Angiogenesis
C Sun, SB Feng, ZW Cao, JJ Bei, Q Chen, WB Zhao, XJ Xu, Z Zhou, ZP Yu, HY Hu
Cell. Physiol. Biochem., 2017;41(6):2319-2332.
Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3 methylbutanamides.
Tuccinardi et al.
Bioorg.Med.Chem., 2006;14:4260

Product Datasheets

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Citations for ARP 101

The citations listed below are publications that use Tocris products. Selected citations for ARP 101 include:

3 Citations: Showing 1 - 3

Up-Regulated Expression of Matrix Metalloproteinases in Endothelial Cells Mediates Platelet Microvesicle-Induced Angiogenesis.
Authors: Sun Et al.
Cell Physiol Biochem 2017;41:2319
PDGF-stimulated dispersal of cell clusters and disruption of fibronectin matrix on three-dimensional collagen matrices requires matrix metalloproteinase-2.
Authors: Rocha-Azevedo Et al.
Hum Reprod 2015;26:1098
NME1 suppression promotes growth, adhesion and implantation of endometrial stromal cells via Akt and MAPK/Erk1/2 signal pathways in the endometriotic milieu.
Authors: Li Et al.
Oncotarget 2013;28:2822

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