AR-C 69931 tetrasodium salt
Chemical Name: N-[2-(Methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]adenosine-5'-O-(β,γ-dichloromethylene)triphosphate tetrasodium salt
Purity: ≥98%
Biological Activity
AR-C 69931 tetrasodium salt is a highly potent P2Y12 antagonist (IC50 = 0.4 nM). Inhibits ADP-induced human platelet aggregation ex vivo. Reduces thrombus weight and delays thrombus formation in a model of carotid artery thrombosis in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Prevention of arterial thrombosis by intravenously administered platelet P2T receptor antagonist AR-C69931MX in a canine model.
Huang et al.
J.Pharmacol.Exp.Ther., 2000;295:492 -
Antagonists of the platelet P2T receptor: a novel approach to antithrombotic therapy.
Ingall et al.
J.Med.Chem., 1999;42:213 -
The P2Y12 antagonists, 2-methylthioadenosine 5'-monophosphate triethylammonium salt and cangrelor (ARC69931MX), can inhibit human platelet aggregation through a Gi-independent increase in cAMP levels.
Srinivasan et al.
J.Biol.Chem., 2009;284:16108
Product Datasheets
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Citations for AR-C 69931 tetrasodium salt
The citations listed below are publications that use Tocris products. Selected citations for AR-C 69931 tetrasodium salt include:
6 Citations: Showing 1 - 6
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Neuronal hyperexcitability is a DLK-dependent trigger of herpes simplex virus reactivation that can be induced by IL-1.
Authors: Chris Et al.
Elife 2020;9
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Three-dimensional growth of breast cancer cells potentiates the anti-tumor effects of unacylated ghrelin and AZP-531.
Authors: Vivek Et al.
Elife 2020;9
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Cancer associated fibroblast FAK regulates malignant cell metabolism.
Authors: Yu Et al.
Nat Commun 2020;11:1290
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Promiscuous G-Protein-Coupled Receptor Inhibition of Transient Receptor Potential Melastatin 3 Ion Channels by Gβγ Subunits.
Authors: Sally Et al.
J Neurosci 2019;39:7840-7852
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The P2Y12 Receptor Antagonist Ticagrelor Reduces Lysosomal pH and Autofluorescence in Retinal Pigmented Epithelial Cells From the ABCA4-/- Mouse Model of Retinal Degeneration.
Authors: Lu Et al.
Front Pharmacol 2018;9:242
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Activation of group II metabotropic glutamate receptors induces long-term depression of synaptic transmission in the rat amygdala.
Authors: H C Et al.
J Neurosci 2000;20:9017-24
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