AR-C 66096 tetrasodium salt

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Background References

1. SDF-1alpha is a novel autocrine activator of platelets operating through its receptor CXCR4.
   Walsh T, Harper M, Poole A
   Cell Signal, 2015;27(1):37-46.
2. RhoG protein regulates platelet granule secretion and thrombus formation in mice.
   Goggs R, Harper M, Pope R, Savage J, Williams C, Mundell S, Heesom K, Bass M, Mellor H, Poole A
   J Biol Chem, 2013;288(47):34217-29.
3. Circulating primers enhance platelet function and induce resistance to antiplatelet therapy.
   Blair T, Moore S, Hers I
   J Thromb Haemost, 2015;13(8):1479-93.
4. FPL 66096: a novel, highly potent and selective antagonist at human platelet P2T-purinoceptors.
   Humphries et al.
   Br.J.Pharmacol., 1994;113:1057
5. Antagonists of the platelet P receptor: a novel approach to antithrombotic therapy.
   Ingall et al.
   J.Med.Chem., 1999;42:213
6. Activity of adenosine diphosphates and triphosphates on a P2YT-type receptor in brain capillary endothelial cells.
   Simon et al.
   Br.J.Pharmacol., 2001;132:173

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