Home / GSK-3 Inhibitors / AR-A 014418

AR-A 014418

Catalog #: 3966
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3966/10
3966/50
AR-A 014418 | CAS No. 487021-52-3 | GSK-3 Inhibitors
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Description: Selective GSK-3 inhibitor

Chemical Name: N-[(4-Methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)urea

Purity: ≥99%

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

AR-A 014418 is a selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50 = 104 nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC50 values are > 100 μM) and over 26 other kinases. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices.

Technical Data

M.Wt:
308.31
Formula:
C12H12N4O4S
Solubility:
Soluble to 100 mM in DMSO and to 5 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
487021-52-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of AstraZeneca UK Ltd.

Product Datasheets

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Citations for AR-A 014418

The citations listed below are publications that use Tocris products. Selected citations for AR-A 014418 include:

4 Citations: Showing 1 - 4

  1. Interleukin-1β drives NEDD8 nuclear-to-cytoplasmic translocation, fostering parkin activation via NEDD8 binding to the P-ubiquitin activating site.
    Authors: Ling Et al.
    J Neuroinflammation  2019;16:275
  2. GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation.
    Authors: Penas Et al.
    Tuberc Respir Dis (Seoul)  2015;14:417
  3. GSK3β Inhibition Promotes Synaptogenesis in Drosophila and Mammalian Neurons.
    Authors: Cuesto Et al.
    PLoS One  2015;10:e0118475
  4. Spatially coordinated kinase signaling regulates local axon degeneration.
    Authors: Chen Et al.
    J Neurosci  2012;32:13439

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