Amyloid β-Peptide (1-42) (human)
Purity: ≥95%
Biological Activity
Amyloid β-Peptide (1-42) (human) is a human form of the predominant amyloid β-peptide found in the brains of patients with Alzheimer's disease. Downregulates bcl-2 and increases the levels of bax. Neurotoxic.Control Peptide also available.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
-
A? accumulation causes MVB enlargement and is modelled by dominant negative VPS4A
K Willén, JR Edgar, T Hasegawa, N Tanaka, CE Futter, GK Gouras
Mol Neurodegener, 2017;12(1):61. -
Matriptase cleaves the amyloid-beta peptide 1-42 at Arg-5, Lys-16, and Lys-28
LM Chen, KX Chai
BMC Res Notes, 2019;12(1):5. -
Amyloid β-protein induces the cerebrovascular cellular pathology of Alzheimer's disease and related disorders.
Van Nostrand et al.
Ann.N.Y.Acad.Sci., 1996;777:297 -
Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein.
Glenner and Wong
Biochem.Biophys.Res.Commun., 1984;120:885 -
Amyloid beta peptide of Alzheimer's disease downregulates bcl-2 and upregulates bax expression in human neurons.
Paradis et al.
J.Neurosci., 1996;16:7533
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citations for Amyloid β-Peptide (1-42) (human)
The citations listed below are publications that use Tocris products. Selected citations for Amyloid β-Peptide (1-42) (human) include:
6 Citations: Showing 1 - 6
-
ApoE-fragment/Aβ heteromers in the brain of patients with Alzheimer's disease.
Authors: Mouchard Et al.
Sci Rep 2019;9:3989
-
Matriptase cleaves the amyloid-beta peptide 1-42 at Arg-5, Lys-16, and Lys-28.
Authors: Chen and Chai
BMC Res Notes 2019;12:5
-
Non-Neuronal Cells Are Required to Mediate the Effects of Neuroinflammation: Results from a Neuron-Enriched Culture System.
Authors: Hui Et al.
PLoS One 2016;11:e0147134
-
Preventing effect of L-type calcium channel blockade on electrophysiological alterations in dentate gyrus granule cells induced by entorhinal amyloid pathology.
Authors: Pourbadie Et al.
J Neuroinflammation 2015;10:e0117555
-
β-amyloid induces a dying-back process and remote trans-synaptic alterations in a microfluidic-based reconstructed neuronal network.
Authors: Deléglise Et al.
Acta Neuropathol Commun 2014;2:145
-
Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-α.
Authors: Scuderi Et al.
Dent Res J (Isfahan) 2012;9:49
FAQs
No product specific FAQs exist for this product, however you may
View all Peptide FAQsReviews for Amyloid β-Peptide (1-42) (human)
There are currently no reviews for this product. Be the first to review Amyloid β-Peptide (1-42) (human) and earn rewards!
Have you used Amyloid β-Peptide (1-42) (human)?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
