AMG 837 hemicalcium salt
Chemical Name: (βS)-β-1-Propyn-1-yl-4-[[4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]methoxy]benzenepropanoic acid hemicalcium salt
Purity: ≥98%
Biological Activity
AMG 837 hemicalcium salt is a potent free fatty acid receptor 1 (FFA1/GPR40) partial agonist (EC50 values are 13.5, 22.6 and 31.7 nM at human, mouse and rat receptors, respectively). Interacts allosterically with full FFA1 agonist Docosahexaenoic acid (Cat. No. 3687). Potentiates glucose-dependent stimulation of insulin in vivo. Antidiabetic.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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AMG 837: a potent, orally bioavailable GPR40 agonist.
Houze et al.
Bioorg.Med.Chem.Lett., 2012;22:1267 -
Identification and pharmacological characterization of multiple allosteric binding sites on the free fatty acid 1 receptor.
Lin et al.
Mol.Pharmacol., 2012;82:843 -
AMG 837: a novel GPR40/FFA1 agonist that enhances Ins secretion and lowers glucose levels in rodents.
Lin et al.
PLoS One, 2011;6:e27270
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