AM 80

Biological Activity

AM 80 is a retinoic acid receptor α (RARα) agonist that induces differentiation (ED₅₀ = 0.79 nM) and apoptosis of HL-60 cells in vitro. Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 μM respectively) and displays anticancer activity against acute promyelocytic leukemia in vivo. AM 80 is a cell cycle activator in hiPSC-derived cardiomyocytes, and pretreatment with AM 80 promotes engraftment of cardiomyocytes in mice with heart damage.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. GSK3 is a regulator of RAR-mediated differentiation.
   Gupta K, Gulen F, Sun L
   Leukemia, 2012;26(6):1277-85.
2. Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity.
   Kagechika et al.
   J.Med.Chem., 1988;31:2182
3. RARα is a regulatory factor for Am-80-induced cell growth inhibition of hematologic malignant cells.
   Jimi et al.
   Int.J.Oncol., 2007;31:397
4. The effects of Am-80, a synthetic retinoid, on spinal cord injury-induced motor dysfunction in rats.
   Takenaga et al.
   Biol.Pharm.Bull., 2009;32:225

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