AM 580

Biological Activity

AM 580 synthesized to Ancillary Material Grade also available.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations
   JH Lee, SI Protze, Z Laksman, PH Backx, GM Keller
   Cell Stem Cell, 2017;21(2):179-194.e4.
2. Retinoids induce integrin-independent lymphocyte adhesion through RAR-alpha nuclear receptor activity.
   Whelan J, Wang L, Chen J, Metts M, Nasser T, McGoldrick L, Bridges L
   Biochem Biophys Res Commun, 2014;454(4):537-542.
3. Direct Reprogramming of Fibroblasts via a Chemically Induced XEN-like State
   X Li, D Liu, Y Ma, X Du, J Jing, L Wang, B Xie, D Sun, S Sun, X Jin, X Zhang, T Zhao, J Guan, Z Yi, W Lai, P Zheng, Z Huang, Y Chang, Z Chai, J Xu, H Deng
   Cell Stem Cell, 2017;0(0):.
4. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
   Fox JT, Sakamuru S, Huang R
   Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
5. Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1.
   Wang et al.
   Proc.Natl.Acad.Sci.U.S.A., 2011;108:18283
6. Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity.
   Kagechika et al.
   J.Med.Chem., 1988;31:2182
7. Novel non-carboxylic acid retinoids: 1,2,4-oxadiazol-5-one derivatives.
   Charton et al.
   Bioorg.Med.Chem.Lett., 2009;19:489
8. The retinoic acid receptor-α mediates human T-cell activation and Th2 cytokine and chemokine production.
   Dawson et al.
   BMC Immunol., 2008;9:16

Product Datasheets