Alantolactone
Chemical Name: (3aR,5S,8aR,9aR)-3a,5,6,7,8,8a,9,9a-Octahydro-5,8a-dimethyl-3-methylenenaphtho[2,3-b]furan-2(3H)-one
Purity: ≥98%
Biological Activity
Alantolactone is a sesquiterpene lactone. Induces activin/SMAD3 signaling and disrupts Cripto-1/activin receptor type II A interaction. Displays antiproliferative activity in human colon adenocarcinoma HCT-8 cells.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Toxic effect of alantolactone and dihydroalantolactone in in vitro cultures of leukocytes.
Dupuis & Brisson et al.
Chem.Biol.Interact., 1976;15:205 -
Alantolactone inhibits cell proliferation by interrupting the interaction between Cripto-1 and AVNreceptor type II A in AVNsignaling pathway.
Shi et al.
J.Biomol.Screen., 2011;16:525 -
Activation of caspases and poly (ADP-ribose) polymerase cleavage to induce apoptosis in leukemia HL-60 cellsby Inula racemosa.
Pal et al.
Toxicol.In Vitro., 2010;24:1599
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