AGN 193109
Chemical Name: 4-[2-[5,6-Dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl]ethynyl]benzoic acid
Purity: ≥98%
Biological Activity
AGN 193109 is a high affinity pan-retinoic acid receptor (RAR) antagonist (Kd values are 2, 2 and 3 nM at RARα, RARβ and RARγ, respectively). Exhibits no significant affinity for retinoic X receptors. AGN 193109 promotes the differentiation from mouse embryonic stem cells into paraxial mesoderm. AGN 193109 suppresses primary human cardiovascular smooth muscle cell calcification.AGN 193109 synthesized to Ancillary Material Grade also available.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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IL-2 Enhances Gut Homing Potential of Human Naive Regulatory T Cells Early in Life
PS Hsu, CL Lai, M Hu, B Santner-Na, JE Dahlstrom, CH Lee, A Ajmal, A Bullman, S Arbuckle, A Al Saedi, L Gacis, R Nambiar, A Williams, M Wong, DE Campbell, R Nanan
J. Immunol., 2018;0(0):. -
Stemness marker ALDH1A1 promotes tumor angiogenesis via retinoic acid/HIF-1?/VEGF signalling in MCF-7 breast cancer cells
V Ciccone, E Terzuoli, S Donnini, A Giachetti, L Morbidelli, M Ziche
J. Exp. Clin. Cancer Res., 2018;37(1):311. -
AGN193109 is a highly effective antagonist of retinoid action in human ectocervical epithelial cells.
Agarwal et al.
J.Biol.Chem., 1996;271:12209 -
Saturated fatty acids regulate retinoic acid signalling and suppress tumorigenesis by targeting fatty acid-binding protein 5
Levi et al.
Nat.Commun., 2015;6:8794 -
Zic1 controls placode progenitor formation non-cell autonomously by regulating retinoic acid production and transport.
Jaurena et al.
Nat.Commun., 2015;6:7476
Product Datasheets
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Citations for AGN 193109
The citations listed below are publications that use Tocris products. Selected citations for AGN 193109 include:
7 Citations: Showing 1 - 7
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Regulation of prefrontal patterning and connectivity by retinoic acid.
Authors: Gabriel Et al.
Nature 2021;598:483-488
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CD137 Signaling Regulates Acute Colitis via RALDH2-Expressing CD11b-CD103+ DCs.
Authors: Seungwoon Et al.
Cell Rep 2020;30:4124-4136.e5
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Fattening chips: hypertrophy, feeding, and fasting of human white adipocytes in vitro.
Authors: Chad A Et al.
Lab Chip 2020;20:4152-4165
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Timed Collinear Activation of Hox Genes during Gastrulation Controls the Avian Forelimb Position.
Authors: Moreau Et al.
Curr Biol 2019;29:35
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ALDH3A1 Overexpression in Melanoma and Lung Tumors Drives Cancer Stem Cell Expansion, Impairing Immune Surveillance through Enhanced PD-L1 Output.
Authors: Marina Et al.
Cancers (Basel) 2019;11
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Glycemic Variability Promotes Both Local Invasion and Metastatic Colonization by Pancreatic Ductal Adenocarcinoma.
Authors: Jian Et al.
Cell Mol Gastroenterol Hepatol 2018;6:429
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Zinc finger gene nolz1 regulates the formation of retinal progenitor cells and suppresses the Lim3/Lhx3 phenotype of retinal bipolar cells in chicken retina.
Authors: Blixt Et al.
Dev Dyn 2018;247:630
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