AG 205
Chemical Name: cis-2-[[1-(4-Chlorophenyl)-1H-tetrazol-5-yl]thio]-1-(1,2,3,4,4a,9b-hexahydro-2,8-dimethyl-5H-pyrido[4,3-b]indol-5-yl)-ethanone
Purity: ≥97%
Biological Activity
AG 205 is a progesterone receptor membrane component 1 (Pgrmc1) ligand. Inhibits cell cycle progression and cell viability in cancer cell lines. Inhibits progesterone induced cytosolic Ca2+ increases in GnRH neurons in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Progesterone receptor membrane component 1 (Pgrmc1): a heme-1 domain protein that promotes tumorigenesis and is inhibited by a small molecule.
Ahmed et al.
J.Pharmacol.Exp.Ther., 2010;333:564 -
Progesterone directly and rapidly inhibits GnRH neuronal activity via progesterone receptor membrane component 1.
Bashour and Wray
Endocrinology., 2012;153:4457 -
A structure-based strategy for discovery of small ligands binding to functionally unknown proteins: combination of in silico screening and surface plasmon resonance measurements.
Yoshitani et al.
Proteomics., 2005;5:1472 -
The PGRMC1 Antagonist AG-205 Inhibits Synthesis of Galactosylceramide and Sulfatide
L Wang-Eckha, I Becker, M Eckhardt
Cells, 2021;10(12):.
Product Datasheets
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Citations for AG 205
The citations listed below are publications that use Tocris products. Selected citations for AG 205 include:
2 Citations: Showing 1 - 2
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PGRMC1 acts as a size-selective cargo receptor to drive ER-phagic clearance of mutant prohormones.
Authors: Leena Et al.
Nat Commun 2021;12:5991
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The PGRMC1 Antagonist AG-205 Inhibits Synthesis of Galactosylceramide and Sulfatide.
Authors: Matthias Et al.
Cells 2021;10
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