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Adenine

Catalog #: 4202 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4202/50
Adenine | CAS No. 2922-28-3 | Adenine Receptor Agonists
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Description: Adenine receptor agonist

Chemical Name: 6-Aminopurine hydrochloride

Purity: ≥99%

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Biological Activity

Adenine is a high affinity adenine receptor agonist (Ki = 18 nM at rat adenine receptor). Inhibits forskolin-stimulated cAMP formation in CHO cells transfected with the adenine receptor; also stimulates GTPγS binding (pEC50 values are 8.54 and 7.21 respectively).

Technical Data

M.Wt:
171.59
Formula:
C5H5N5.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
2922-28-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Evidence for the functional expression and pharmacological characterization of adenine receptors in native cells and tissues.
    Gorzalka et al.
    Mol.Pharmacol., 2005;67:955
  2. Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule.
    Bender et al.
    Proc.Natl.Acad.Sci., 2002;99:8573

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