Adaptaquin
Chemical Name: 7-[(4-Chlorophenyl)[(3-hydroxy-2-pyridinyl)amino]methyl]-8-quinolinol
Purity: ≥97%
Biological Activity
Adaptaquin is a HIF-prolyl hydroxylase-2 (PHD2) inhibitor. Blocks glutamate induced ROS production in HT-22 cells, independent of MnSOD. Exhibits neuroprotective effects and enhances functional recovery in rodent intracerebral hemorrhage models, via inhibition of ATF4 dependent genes. Brain penetrant. Also antioxidant.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models.
Karuppagounder et al.
Sci.Transl.Med., 2016;8:328ra29 -
Inhibition of HIF-prolyl-4-hydroxylases prevents mitochondrial impairment and cell death in a model of neuronal oxytosis.
Neitemeier et al.
Cell Death Dis., 2016;7:e2214
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Citation for Adaptaquin
The citations listed below are publications that use Tocris products. Selected citations for Adaptaquin include:
1 Citation: Showing 1 - 1
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HIF1α stabilization in hypoxia is not oxidant-initiated.
Authors: Saravanan S Et al.
Elife 2021;10
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