AC 55541

Catalog #: 3369
6 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
3369/10
3369/50

AC 55541 | CAS No. 916170-19-9 | Protease-Activated Receptor Agonists

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Description: Potent and selective PAR2 agonist

Chemical Name: (2E)-2-[1-(3-Bromophenyl)ethylidene] α-(benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineacetic acid hydrazide

Purity: ≥97%

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Product Details

Citations (6)

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Biological Activity

AC 55541 is a potent and selective protease-activated receptor 2 (PAR₂) agonist (pEC₅₀ = 6.7) that displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation. Stimulates cell proliferation, PI hydrolysis and Ca²⁺ mobilization in vitro (pEC₅₀ values are 6.7, 5.9 and 6.6 respectively) and exhibits pronociceptive activity in vivo.

Technical Data

M.Wt:

518.36

Formula:

C₂₅H₂₀BrN₅O₃

Solubility:

Soluble to 50 mM in DMSO

Purity:

≥97%

Storage:

Store at -20°C

CAS No:

916170-19-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Discovery of potent and selective small-molecule PAR-2 agonists.
Seitzberg et al.
J.Med.Chem., 2008;51:5490
Identification and characterization of novel small-molecule protease-activated receptor 2 agonists.
Gardell et al.
J.Pharmacol.Exp.Ther., 2008;327:799

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Citations for AC 55541

The citations listed below are publications that use Tocris products. Selected citations for AC 55541 include:

6 Citations: Showing 1 - 6

Identification and therapeutic rescue of autophagosome and glutamate receptor defects in C9ORF72 and sporadic ALS neurons.
Authors: Shi Et al.
JCI Insight 2019;5
Exosome-mediated uptake of mast cell tryptase into the nucleus of melanoma cells: a novel axis for regulating tumor cell proliferation and gene expression.
Authors: Melo Et al.
Cell Death Dis 2019;10:659
Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction.
Authors: Shi Et al.
J Immunol 2015;21:4852
A brief exposure to tryptase or thrombin potentiates fibrocyte differentiation in the presence of serum or serum amyloid p.
Authors: White Et al.
Mol Pain 2015;194:142
Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells.
Authors: Tripathi Et al.
Invest Ophthalmol Vis Sci 2014;55:3912
Contribution of TRPC3 to store-operated calcium entry and inflammatory transductions in primary nociceptors.
Authors: Alkhani Et al.
Neuropsychopharmacology 2014;10:43

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