Home / Protease-Activated Receptor Agonists / AC 264613

AC 264613

Catalog #: 3370 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3370/10
3370/50
AC 264613 | CAS No. 1051487-82-1 | Protease-Activated Receptor Agonists
1 Image
Description: PAR2 receptor agonist

Chemical Name: (±)-(3R*,4S*)-2-Oxo-4-phenyl-3-pyrollidinecarboxylic acid 2-[1-(3-bromophenyl)ethylidene]hydrazide

Purity: ≥98%

Product Details
Supplemental Products
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

AC 264613 is a potent and selective protease-activated receptor 2 (PAR2) agonist (pEC50 = 7.5). Displays no activity at other PAR subtypes and exhibits no significant activity at over 30 other receptors implicated in nociception and inflammation. Stimulates PI hydrolysis, Ca2+ mobilization and cellular proliferation in vitro (pEC50 values are 6.9, 7.0 and 7.5 respectively).

Technical Data

M.Wt:
400.27
Formula:
C19H18BrN3O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1051487-82-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Discovery of potent and selective small-molecule PAR-2 agonists.
    Seitzberg et al.
    J.Med.Chem., 2008;51:5490
  2. Identification and characterization of novel small-molecule protease-activated receptor 2 agonists.
    Gardell et al.
    J.Pharmacol.Exp.Ther., 2008;327:799

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs
Loading...

Reviews for AC 264613

There are currently no reviews for this product. Be the first to review AC 264613 and earn rewards!

Have you used AC 264613?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.