AA 147

Catalog #: 6759
5 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
6759/5
6759/25

AA 147 | CAS No. 393121-74-9 | Other ER Stress/UPR Activators

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Description: ER proteostasis regulator

Chemical Name: N-(2-Hydroxy-5-methylphenyl)benzenepropanamide

Purity: ≥98%

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Product Details

Citations (5)

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

AA 147 is an endoplasmic reticulum (ER) proteostasis regulator. Activates the ATF6 transcriptional program independently of ER stress and/or global UPR activation. Selectively reduces secretion of amyloidogenic transthyretin (TTR) from HepG2 cells. Reduces amyloidogenic immunoglobulin light chain (ALLC) secretion from ALMC-2 cells (EC₅₀ = 1.1 μM).

Technical Data

M.Wt:

255.31

Formula:

C₁₆H₁₇NO₂

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

≥98%

Storage:

Store at +4°C

CAS No:

393121-74-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation.
Plate et al.
Elife, 2016;5:e15550

Product Datasheets

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M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for AA 147

The citations listed below are publications that use Tocris products. Selected citations for AA 147 include:

5 Citations: Showing 1 - 5

Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death.
Authors: Jochen H M Et al.
Nat Commun 2023;14:2132
Scleral PERK and ATF6 as targets of myopic axial elongation of mouse eyes.
Authors: Xiaoyan Et al.
Nat Commun 2022;13:5859
Pharmacological Activating Transcription Factor 6 Activation Is Beneficial for Liver Retrieval With ex vivo Normothermic Mechanical Perfusion From Cardiac Dead Donor Rats.
Authors: Yang Et al.
Front Surg 2021;8:665260
In vivo screen identifies a SIK inhibitor that induces β cell proliferation through a transient UPR.
Authors: Peng Et al.
Nat Metab 2021;3:682-700
Activation of the ATF6 (Activating Transcription Factor 6) Signaling Pathway in Neurons Improves Outcome After Cardiac Arrest in Mice.
Authors: Shu Et al.
J Am Heart Assoc 2021;10:e020216

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