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A01

Catalog #: 5397 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5397/10
5397/50
A01 | CAS No. 1007647-73-5 | Ubiquitin Ligase (E3) Inhibitors
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Description: High affinity Smurf1 inhibitor; enhances BMP signaling

Chemical Name: [4-[[4-Chloro-3-(trifluoromethyl)phenyl]sulfonyl]-1-piperazinyl][4-(5-methyl-1H-pyrazol-1-yl)phenyl]methanone

Purity: ≥98%

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Biological Activity

A01 is a high affinity Smurf1 E3 ubiquitin ligase inhibitor (Kd = 3.7 nM). Attenuates Smurf1-mediated Smad 1/5 degradation and enhances BMP signaling. Potentiates BMP-2-induced osteoblastic activity in C2C12 myoblasts and MC3T3-E1 osteoblast precursor cells.

Technical Data

M.Wt:
512.93
Formula:
C22H20ClF3N4O3S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1007647-73-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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