A 779
Purity: ≥95%
Biological Activity
A 779 is a selective Mas receptor (Ang-(1-7) receptor) antagonist. Exhibits no significant affinity for AT1 or AT2 receptors at a concentration of 1 μM. Inhibits antidiuretic effect of Ang-(1-7) in water-loaded rats. Also attenuates Monocrotaline-induced pulmonary fibrosis in rats.Technical Data
(Modifications: Ala-7 = D-Ala)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Selective activation of angiotensin AT2 receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis.
Bruce et al.
Br.J.Pharmacol., 2015;172:2219 -
Cardiovascular effects of angiotensin II and angiotensin-(1-7) at the RVLM of trained normotensive rats.
Becker et al.
Brain Res., 2005;1040:121 -
Characterization of a new angiotensin antagonist selective for angiotensin-(1-7): evidence that the actions of angiotensin-(1-7) are mediated by specific angiotensin receptors.
Santos et al.
Brain Res.Bull., 1994;35:293
Product Datasheets
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Citations for A 779
The citations listed below are publications that use Tocris products. Selected citations for A 779 include:
6 Citations: Showing 1 - 6
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The spike of SARS-CoV-2 promotes metabolic rewiring in hepatocytes.
Authors: Felix Et al.
Commun Biol 2022;5:827
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Angiotensinergic receptors in the medial amygdaloid nucleus differently modulate behavioral responses in the elevated plus-maze and forced swimming test in rats.
Authors: Moreno-Santos Et al.
Behav.Brain Res. 2021;397
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The Impact of Ang-(1-9) and Ang-(3-7) on the Biological Properties of Prostate Cancer Cells by Modulation of Inflammatory and Steroidogenesis Pathway Genes.
Authors: Tomasz Et al.
Int J Mol Sci 2020;21
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Blockade of the renin-angiotensin system suppresses hydroxyl radical production in the rat striatum during carbon monoxide poisoning.
Authors: Hajime Et al.
Sci Rep 2020;10:2602
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Subcutaneous Administration of Angiotensin-(1-7) Improves Recovery after Traumatic Brain Injury in Mice.
Authors: Aviva J Et al.
J Neurotrauma 2019;36:3115-3131
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Angiotensin 1-7 modulates molecular and cellular processes central to the pathogenesis of prostate cancer.
Authors: Dominska Et al.
Sci.Rep. 2018;8:15772
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