A 77636 hydrochloride
Chemical Name: (1R-cis)-1-(Aminomethyl)-3,4-dihydro-3-tricyclo[3.3.1.13,7]dec-1-yl-[1H]-2-benzopyran-5,6-diol hydrochloride
Purity: ≥98%
Biological Activity
A 77636 hydrochloride is a potent and selective dopamine D1-like receptor agonist (pEC50 values are 8.97 and < 5 for D1-like and D2-like receptors respectively). Displays anti-Parkinsonian activity following oral administration in vivo. Exhibits 11-fold cell type bias over dopamine in a functional assay in U2 cells.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Inhibitory Effects of Dopamine Receptor D1 Agonist on Mammary Tumor and Bone Metastasis
K Minami, S Liu, Y Liu, A Chen, Q Wan, S Na, BY Li, N Matsuura, M Koizumi, Y Yin, L Gan, A Xu, J Li, H Nakshatri, H Yokota
Sci Rep, 2017;7(0):45686. -
The potent and selective DA D1 receptor agonist A-77636 increases cortical and hippocampal acetylcholine release in the rat.
Acquas et al.
Eur.J.Pharmacol., 1994;260:85 -
Homologous desensitization of the D1A DA receptor: efficacy in causing desensitization dissociates from both receptor occupancy and functional potency.
Lewis et al.
J.Pharmacol.Exp.Ther., 1998;286:345 -
A-77636: a potent and selective DA D1 receptor agonist with antiparkinsonian activity in marmosets.
Kebabian et al.
Eur.J.Pharmacol., 1992;229:203
Product Datasheets
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Citations for A 77636 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for A 77636 hydrochloride include:
5 Citations: Showing 1 - 5
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The small molecule CA140 inhibits the neuroinflammatory response in wild-type mice and a mouse model of AD.
Authors: Lee Et al.
J Neuroinflammation 2018;15:286
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Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence.
Authors: Chai Et al.
Neuron 2017;95:531
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Nucleus accumbens D2R cells signal prior outcomes and control risky decision-making.
Authors: Zalocusky Et al.
Nature 2016;531:642
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Stimulation of the D5 DA receptor acidifies the lysosomal pH of retinal pigmented epithelial cells and decreases accumulation of autofluorescent photoreceptor debris.
Authors: Guha Et al.
J Neurochem 2012;122:823
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Target identification by chromatographic co-elution: monitoring of drug-protein interactions without immobilization or chemical derivatization.
Authors: Chan Et al.
Mol Cell Proteomics 2012;11:M111.016642
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