Home / Dopamine D1 and D5 Receptor Agonists / A 68930 hydrochloride

A 68930 hydrochloride

Catalog #: 1534
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1534/10
1534/50
A 68930 hydrochloride | CAS No. 130465-39-3 | Dopamine D1 and D5 Receptor Agonists
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Description: Potent and selective D1-like agonist

Chemical Name: cis-(±)-1-(Aminomethyl)-3,4-dihydro-3-phenyl-1H-2-benzopyran-5,6-diol hydrochloride

Purity: ≥98%

Product Details
Citations (3)
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Biological Activity

A 68930 hydrochloride is a potent and selective D1-like dopamine receptor agonist (EC50 values are 2.1 and 3910 nM for D1-like and D2-like receptors respectively). Centrally active following systemic administration in vivo.

Technical Data

M.Wt:
307.78
Formula:
C16H17NO3.HCl
Solubility:
Soluble to 50 mM in water
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
130465-39-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Phosphorylation of mouse melanopsin by protein kinase a.
    Blasic, Joseph R, Brown, R Lane, Robinson, Phyllis
    PLoS ONE, 2012;7(9):e45387.
  2. Psychopharmacological distinction between novel full-efficacy "D1-like" DA receptor agonists.
    Deveney and Waddingto
    Pharmacol.Biochem.Behav., 1997;58:551
  3. A68930: a potent and specific agonist for the D-1 DA receptor.
    Kebabian et al.
    Am.J.Hypertens., 1990;3:40S
  4. (1R,3S)-1-(Aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist.
    Quaglia et al.
    J.Med.Chem., 1990;33:2948

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Citations for A 68930 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for A 68930 hydrochloride include:

3 Citations: Showing 1 - 3

  1. The DA D1 receptor is expressed and facilitates relaxation in airway smooth muscle.
    Authors: Mizuta Et al.
    PLoS One  2013;14:89
  2. Phosphorylation of mouse melanopsin by protein kinase A.
    Authors: Blasic Et al.
    Sci Rep  2012;7:e45387
  3. Stimulation of the D5 DA receptor acidifies the lysosomal pH of retinal pigmented epithelial cells and decreases accumulation of autofluorescent photoreceptor debris.
    Authors: Guha Et al.
    J Neurochem  2012;122:823

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