Home / CaM Kinase Inhibitors / A 484954

A 484954

Catalog #: 4483
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4483/10
4483/50
A 484954 | CAS No. 142557-61-7 | CaM Kinase Inhibitors
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Description: CaM kinase III (eEF-2 kinase) inhibitor

Chemical Name: 7-Amino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxopyrido[2,3-d]pyrimidine-6-carboxamide

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

A 484954 is an inhibitor of eukaryotic elongation factor-2 (eEF-2) kinase (IC50 = 0.28 μM in enzymatic assay). Reduces eEF-2 phosphorylation with little effect on cancer cell growth.

Technical Data

M.Wt:
289.29
Formula:
C13H15N5O3
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
142557-61-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for A 484954

The citations listed below are publications that use Tocris products. Selected citations for A 484954 include:

2 Citations: Showing 1 - 2

  1. eEF2K Activity Determines Synergy to Cotreatment of Cancer Cells With PI3K and MEK Inhibitors.
    Authors: Pedro R Et al.
    Mol Cell Proteomics  2022;21:100240
  2. The Global Phosphorylation Landscape of SARS-CoV-2 Infection
    Authors: Bouhaddou Et al.
    Cell  2020;182:685

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