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A 1070722

Catalog #: 4431 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4431/10
4431/50
A 1070722 | CAS No. 1384424-80-9 | GSK-3 Inhibitors
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Description: Highly potent, selective GSK-3 inhibitor

Chemical Name: 1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea

Purity: ≥99%

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Biological Activity

A 1070722 is a potent glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 0.6 nM for GSK-3α and GSK-3β). Displays high selectivity (> 50-fold) for GSK-3 over a panel of other kinases tested, including CDK family members. Decreases phosphorylation of microtubule-associated protein Tau in vitro; protects rat primary cortical neurons against β amyloid and glutamate challenge. Brain penetrant.

Technical Data

M.Wt:
362.31
Formula:
C17H13F3N4O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
1384424-80-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A-1070722, a potent, selective, and centrally active glycogen synthase kinase-3 (GSK-3) inhibitor for the treatment of psychiatric and neurodegenerative disorders.
    Bakker et al.
    Society for Neuroscience (Abstract), 2011;:568

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