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6-Bnz-cAMP sodium salt

Catalog #: 5255
6 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5255/1
6-Bnz-cAMP sodium salt | CAS No. 1135306-29-4 | cAMP Compounds
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Description: Cell permeable cAMP analog

Chemical Name: N-Benzoyladenosine cyclic 3',5'-(hydrogen phosphate) monosodium salt

Purity: ≥98%

Product Details
Citations (6)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

6-Bnz-cAMP sodium salt is a cell permeable cAMP analog; selectively activates cAMP-dependent PKA but not Epac signaling pathways. Acts synergistically with 8-CPT-2Me-cAMP (Cat. No. 1645) to inhibit vascular smooth muscle cell proliferation.

Technical Data

M.Wt:
455.29
Formula:
C17H15N5NaO7P
Solubility:
Soluble to 100 mM in water
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1135306-29-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. PKA and Epac synergistically inhibit smooth muscle cell proliferation.
    Hewer et al.
    J.Mol.Cell Cardiol., 2011;50:87

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Citations for 6-Bnz-cAMP sodium salt

The citations listed below are publications that use Tocris products. Selected citations for 6-Bnz-cAMP sodium salt include:

6 Citations: Showing 1 - 6

  1. A PGE2-MEF2A axis enables context-dependent control of inflammatory gene expression.
    Authors: Marco Et al.
    Immunity  2021;54:1665-1682.e14
  2. Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis.
    Authors: Grant A Et al.
    EMBO J  2020;39:e105111
  3. Osmotic Gradients in Epithelial Acini Increase Mechanical Tension across E-cadherin, Drive Morphogenesis, and Maintain Homeostasis.
    Authors: Jason P Et al.
    Curr Biol  2020;30:624-633.e4
  4. Adenosine Receptor Signaling Targets Both PKA and Epac Pathways to Polarize Dendritic Cells to a Suppressive Phenotype.
    Authors: Caglar Et al.
    J Immunol  2019;203:3247-3255
  5. Functional polarization of human hepatoma HepaRG cells in response to forskolin.
    Authors: Mayati Et al.
    Sci Rep  2018;8:16115
  6. Reactivation of cAMP Pathway by PDE4D Inhibition Represents a Novel Druggable Axis for Overcoming TAX Resistance in ER-positive Breast Cancer.
    Authors: Mishra Et al.
    Clin Cancer Res  2018;24:1987

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