(±)-5'-Chloro-5'-deoxy-ENBA

Catalog #: 3576
2 Citations Datasheet / COA / SDS

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(±)-5'-Chloro-5'-deoxy-ENBA | CAS No. 103626-26-2 | Adenosine A1 Receptor Agonists

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Description: Highly selective A1 agonist

Chemical Name: N-Bicyclo[2.2.1]hept-2-yl-5'-chloro-5'-deoxyadenosine

Purity: ≥98%

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Product Details

Citations (2)

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Biological Activity

(±)-5'-Chloro-5'-deoxy-ENBA is a highly selective adenosine A₁ receptor agonist (K_i values are 0.51, 1290, 1340 and 2740 nM at A₁, A₃, A_2A and A_2B receptors respectively). Reverses formalin-induced nocifensive behavior in mice; antinociceptive.

Technical Data

M.Wt:

379.84

Formula:

C₁₇H₂₂ClN₅O₃

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

103626-26-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

N⁶-bicycloalkyladenosines with unusually high potency and selectivity for the adenosine A1 receptor.
Trivedi et al.
J.Med.Chem., 1989;32:8
N⁶-cycloalkyl- and N⁶-bicycloalkyl-C5'(C2')-modified adenosine derivatives as high-affinity and selective agonists at the human A₁ adenosine receptor with antinociceptive effects in mice.
Franchetti et al.
J.Med.Chem., 2009;52:2393

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Citations for (±)-5'-Chloro-5'-deoxy-ENBA

The citations listed below are publications that use Tocris products. Selected citations for (±)-5'-Chloro-5'-deoxy-ENBA include:

2 Citations: Showing 1 - 2

Adenosine A2A Receptor Activation Enhances Blood-Tumor Barrier Permeability in a Rodent Glioma Model.
Authors: Wei Et al.
Mol Cancer Res 2021;19:2081-2095
Activation of neuronal adenosine A1 receptors causes hypothermia through central and peripheral mechanisms.
Authors: Cuiying Et al.
PLoS One 2020;15:e0243986

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