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5-Amino-Thalidomide

Catalog #: 7678 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7678/100
5-Amino-Thalidomide | CAS No. 191732-76-0 | Degrader Building Blocks
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Description: Cereblon ligand with amine on C5 for onward chemistry

Chemical Name: 5-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione

Purity: ≥95%

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Biological Activity

5-Amino-Thalidomide is a functionalized cereblon (CRBN) ligand for PROTAC® research and development; incorporates an E3 ligase ligand with an amine on the C5 position of the phthalimide ring for onward chemistry to generate Protein Degraders with rigid linkers. Degraders with modifications on the C5 position reduce off-target zinc-finger proteins degradation.

Part of a range of functionalized tool molecules for PROTAC® Degrader R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data

M.Wt:
273.24
Formula:
C13H11N3O4
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
191732-76-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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