4EGI-1

Catalog #: 4800
5 Citations Datasheet / COA / SDS

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4EGI-1 | CAS No. 315706-13-9 | Protein-synthesizing GTPase Compounds

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Description: Inhibits eIF4E:eIF4G subunit interaction

Chemical Name: α-[2-[4-(3,4-Dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-benzenepropanoic acid

Purity: ≥98%

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Product Details

Citations (5)

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

4EGI-1 is an inhibitor of eIF4E:eIF4G interaction; prevents eIF4E binding to eIF4G. Binds eIF4E and inhibits cap-dependent translation but not initiation factor-independent translation. Exhibits activity against Jurkat and A549 cells.

Technical Data

M.Wt:

451.28

Formula:

C₁₈H₁₂Cl₂N₄O₄S

Solubility:

Soluble to 100 mM in DMSO

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

315706-13-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Autism-related deficits via dysregulated eIF4E-dependent translational control.
Gkogkas C, Khoutorsky A, Ran I, Rampakakis E, Nevarko T, Weatherill D, Vasuta C, Yee S, Truitt M, Dallaire P, Major F, Lasko P, Ruggero D, Nader K, Lacaille J, Sonenberg N
Nature, 2013;493(7432):371-7.
Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G.
Moerke et al.
Cell, 2007;128:257

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Citations for 4EGI-1

The citations listed below are publications that use Tocris products. Selected citations for 4EGI-1 include:

5 Citations: Showing 1 - 5

High-throughput translational profiling with riboPLATE-seq.
Authors: Christian Et al.
Sci Rep 2022;12:5718
CUL3 Deficiency Causes Social Deficits and Anxiety-like Behaviors by Impairing Excitation-Inhibition Balance through the Promotion of Cap-Dependent Translation.
Authors: Lei Et al.
Neuron 2020;105:475-490.e6
The Translational Machinery of Human CD4+ T Cells Is Poised for Activation and Controls the Switch from Quiescence to Metabolic Remodeling.
Authors: Rolf Et al.
Cell Metab 2018;28:895-906.e5
Autophagy is a signature of a signaling network that maintains hematopoietic stem cells.
Authors: Michelle Et al.
PLoS One 2017;12:e0177054
Noncanonical SQSTM1/p62-Nrf2 pathway activation mediates proteasome inhibitor resistance in multiple myeloma cells via redox, metabolic and translational reprogramming.
Authors: Riz Et al.
Oncotarget 2016;7:66360

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