Home / Free Fatty Acid Receptor Agonists / 4-CMTB

4-CMTB

Catalog #: 4642
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4642/10
4642/50
4-CMTB | CAS No. 300851-67-6 | Free Fatty Acid Receptor Agonists
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Description: FFA2 agonist; also exhibits positive allosteric modulatory activity

Chemical Name: 4-chloro-α-(1-methylethyl)-N-2-thiazolylbenzeneacetamide

Purity: ≥98%

Product Details
Citations (3)
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Biological Activity

4-CMTB is a free fatty acid receptor FFA2 agonist (pEC50 = 6.38) and positive allosteric modulator. Binds at a site distinct from the orthosteric site; modulates the activity of short-chain fatty acids at FFA2 via the FFA2 second extracellular loop (ECL2).

Technical Data

M.Wt:
294.8
Formula:
C14H15ClN2OS
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
300851-67-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for 4-CMTB

The citations listed below are publications that use Tocris products. Selected citations for 4-CMTB include:

3 Citations: Showing 1 - 3

  1. Identification of the novel role of butyrate as AhR ligand in human intestinal epithelial cells
    Authors: Marinelli Et al.
    Sci.Rep.  2019;9:643
  2. Butyrate Produced by Commensal Bacteria Down-Regulates Indolamine 2,3-Dioxygenase 1 (IDO-1) Expression via a Dual Mechanism in Human Intestinal Epithelial Cells.
    Authors: Martin-Gallausiaux Et al.
    Front Immunol  2019;9:2838
  3. Butyrate produced by gut commensal bacteria activates TGF-beta1 expression through the transcription factor SP1 in human intestinal epithelial cells.
    Authors: Martin-Gallausiaux Et al.
    Sci Rep  2018;8:9742

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