Home / Voltage-gated Potassium Channel Blockers / 4-Aminopyridine

4-Aminopyridine

Catalog #: 0940
32 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
0940/100
4-Aminopyridine | CAS No. 504-24-5 | Voltage-gated Potassium Channel Blockers
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Description: Non-selective KV channel blocker
Alternative Names: 4-AP

Purity: ≥99%

Product Details
Citations (32)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

4-Aminopyridine is a non-selective voltage-dependent K+-channel blocker (IC50 values are 170 and 230 μM at KV1.1 and KV1.2 respectively). Caged 4-AP (Cat. No. 3557) is also available.

Technical Data

M.Wt:
94.12
Formula:
C5H6N2
Solubility:
Soluble to 100 mM in water
Purity:
≥99%
Storage:
Store at RT
CAS No:
504-24-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for 4-Aminopyridine

The citations listed below are publications that use Tocris products. Selected citations for 4-Aminopyridine include:

32 Citations: Showing 1 - 10

  1. NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content.
    Authors: Chiu Et al.
    Cell Rep  2019;28:332
  2. Functional Coupling of Cav2.3 and BK Potassium Channels Regulates Action Potential Repolarization and Short-Term Plasticity in the Mouse Hippocampus.
    Authors: Gutzmann Et al.
    Front Cell Neurosci  2019;13:27
  3. Pathway-specific alterations of cortico-amygdala transmission in an arthritis pain model.
    Authors: Kiritoshi and Neugebauer
    ACS Chem Neurosci  2018;9:2252
  4. Pauses in Cholinergic Interneuron Activity Are Driven by Excitatory Input and Delayed Rectification, with DA Modulation.
    Authors: Zhang Et al.
    Neuron  2018;98:918
  5. Reciprocal Circuits Linking the Prefrontal Cortex with Dorsal and Ventral Thalamic Nuclei.
    Authors: Collins Et al.
    Neuron  2018;98:366
  6. Hypothalamic Circuits for Predation and Evasion.
    Authors: Li Et al.
    Neuron  2018;97:911
  7. Potassium channels contribute to activity-dependent regulation of dendritic inhibition.
    Authors: Chang and Higley
    Physiol Rep  2018;6:e13747
  8. CAST/ELKS Proteins Control Voltage-Gated Ca2+ Channel Density and Synaptic Release Probability at a Mammalian Central Synapse.
    Authors: Dong Et al.
    Cell Rep  2018;24:284
  9. The locus coeruleus drives disinhibition in the midline thalamus via a dopaminergic mechanism.
    Authors: Beas Et al.
    Nat Neurosci  2018;21:963
  10. All-optical synaptic electrophysiology probes mechanism of ketamine-induced disinhibition.
    Authors: Fan Et al.
    Nat Methods  2018;15:823
  11. A Central Catecholaminergic Circuit Controls Blood Glucose Levels during Stress.
    Authors: Zhao Et al.
    Neuron  2017;95:138
  12. Ring finger protein 10 is a novel synaptonuclear messenger encoding activation of NMDA receptors in hippocampus.
    Authors: Dinamarca Et al.
    Elife  2016;5
  13. Tissue plasminogen activator inhibits NMDA-receptor-mediated increases in calcium levels in cultured hippocampal neurons.
    Authors: Robinson Et al.
    J Neurosci  2015;9:404
  14. Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons.
    Authors: Curcio Et al.
    J Neurosci  2015;6:e1645
  15. Corelease of acetylcholine and GABA from cholinergic forebrain neurons.
    Authors: Saunders Et al.
    Front Neural Circuits  2015;4
  16. Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse.
    Authors: Cramer Et al.
    Front Cell Neurosci  2015;35:5664
  17. Neuronal activity induces synaptic delivery of hnRNP A2/B1 by a BDNF-dependent mechanism in cultured hippocampal neurons.
    Authors: Leal Et al.
    PLoS One  2014;9:e108175
  18. Generation of induced neuronal cells by the single reprogramming factor ASCL1.
    Authors: Chanda Et al.
    J Neurosci  2014;3:282
  19. Identification of a pharmacological target for genioglossus reactivation throughout sleep.
    Authors: Grace Et al.
    Elife  2014;37:41
  20. Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation.
    Authors: Chanda Et al.
    J Biol Chem  2013;110:16622
  21. Optophysiological analysis of associational circuits in the olfactory cortex.
    Authors: Hagiwara Et al.
    Cell Death Dis  2012;6:18
  22. Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons.
    Authors: Kaufman Et al.
    Sleep  2012;32:3992
  23. The loop diuretic bumet. blocks posttraumatic p75NTR upregulation and rescues injured neurons.
    Authors: Shulga Et al.
    J Neurosci  2012;32:1757
  24. Interaction between αCaMKII and GluN2B controls ERK-dependent plasticity.
    Authors: Gaamouch Et al.
    J Neurosci  2012;32:10767
  25. Activity-dependent phosphorylation of GABAA receptors regulates receptor insertion and tonic current.
    Authors: Saliba Et al.
    J Neurophysiol  2012;31:2937
  26. The A-current modulates learning via NMDA receptors containing the NR2B subunit.
    Authors: Fontán-Lozano Et al.
    PLoS One  2011;6:e24915
  27. Synaptic autoregulation by metalloproteases and γ-secretase.
    Authors: Restituito Et al.
    J Neurosci  2011;31:12083
  28. An excitatory loop with astrocytes contributes to drive neurons to seizure threshold.
    Authors: Gómez-Gonzalo Et al.
    PLoS Biol  2010;8:e1000352
  29. Experience-dependent intrinsic plasticity in interneurons of barrel cortex layer IV.
    Authors: Sun
    EMBO J  2009;102:2955
  30. Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors.
    Authors: Léveillé Et al.
    FASEB J  2008;22:4258
  31. DArgic modulation of spinal neuronal excitability.
    Authors: Han Et al.
    J Neurophysiol  2007;27:13192
  32. Glutamatergic regulation of the p70S6 kinase in primary mouse neurons.
    Authors: Lenz and Avruch
    Stem Cell Reports  2005;280:38121

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