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2-TEDC

Catalog #: 0645 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
0645/10
0645/50
2-TEDC | CAS No. 132465-10-2 | Lipoxygenase Inhibitors
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Description: 5-, 12-, 15-Lipoxygenase inhibitor

Chemical Name: 2-(1-Thienyl)ethyl 3,4-dihydroxybenzylidenecyanoacetate

Purity: ≥99%

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Biological Activity

2-TEDC is a potent inhibitor of 5-, 12-, and 15-lipoxygenase (IC50 values are 0.09, 0.013 and 0.5 μM respectively).

Technical Data

M.Wt:
315.34
Formula:
C16H13NO4S
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
132465-10-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  2. Novel caffeic acid derivatives - extremely potent inhibitors of 12-lipoxygenase.
    Cho et al.
    J.Med.Chem., 1991;34:1503

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